Martial G. Bourassa, Jean-Claude Tardif's Antioxidants and Cardiovascular Disease (Developments in PDF

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By Martial G. Bourassa, Jean-Claude Tardif

ISBN-10: 0387295526

ISBN-13: 9780387295527

Persistent oxidative tension is linked to the getting older strategy and infrequently ends up in the improvement of issues comparable to melanoma and arterial sickness. Cardiovascular stipulations within which oxidation harm has been strongly implicated comprise atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive center failure. Antioxidants and heart problems, moment variation covers 3 significant issues: 1) the 1st seven chapters evaluation the oxidative modifcation speculation and its shut dating to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the subsequent 4 chapters describe the various compounds, food and supplementations with antioxidant homes and their mechanisms of motion; three) and finallly, the final ten chapters speak about the aptitude merits of antioxidants in total cardiovascular prevention, together with high blood pressure, diabetes mellitus, dyslipidemias, and within the therapy and prevention of particular stipulations resembling power coronary artery affliction, restenosis after percutaneous coronary intervention, and persistent middle failure. Antioxidants and heart problems, moment variation is written by means of well-known specialists within the fields of atherosclerosis, center failure and antioxidants. it's going to be of curiosity to scientific scholars and fellows, researchers, and training physicians. there was speedy growth in our wisdom during this box over the last to 3 years. therefore the present reedition looks well timed. for example, this moment variation captures a number of lately pronounced and released scientific trials as welll as new details on diabetic and hypertensive heart problems.

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Additional resources for Antioxidants and Cardiovascular Disease (Developments in Cardiovascular Medicine), Second Edition

Sample text

Lipoproteins and oxidation 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 37 Savenkova ML, Mueller DM, Heinecke JW. Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein. J Biol Chem 1994;269:20394-400. McNally AK, Chisolm GM, III, Morel DW et al. Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway. J Immunol 1990;145:254-9. Wieland E, Parthasarathy S, Steinberg D.

41. 42. 43. 44. 37 Savenkova ML, Mueller DM, Heinecke JW. Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein. J Biol Chem 1994;269:20394-400. McNally AK, Chisolm GM, III, Morel DW et al. Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway. J Immunol 1990;145:254-9. Wieland E, Parthasarathy S, Steinberg D. Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation?

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001;107:1255-62. Rosenfeld ME. Leukocyte recruitment into developing atherosclerotic lesions: the complex interaction between multiple molecules keeps getting more complex. Arterioscler Thromb Vase Biol 2002;22:361-3. Kunsch C, Medford RM. Oxidative stress as a regulator of gene expression in the vasculature. Circ Res 1999;85:753-66. Marui N, Offermann MK, Swerlick R, et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidantsensitive mechanism in human vascular endothelial cells.

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Antioxidants and Cardiovascular Disease (Developments in Cardiovascular Medicine), Second Edition by Martial G. Bourassa, Jean-Claude Tardif


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